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Applications of RNA interference high-throughput screening technology in cancer biology and virology

Gao, Shan; Yang, Chen; Jiang, Shan; Xu, Xiao-Ning; Lu, Xin; He, You-Wen; Cheung, Annie; Wang, Hui. 2014 Applications of RNA interference high-throughput screening technology in cancer biology and virology. Protein & Cell, 5 (11). 805-815. 10.1007/s13238-014-0076-6

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Abstract/Summary

RNA interference (RNAi) is an ancient intra-cellular mechanism that regulates gene expression and cell function. Large-scale gene silencing using RNAi high-throughput screening (HTS) has opened an exciting frontier to systematically study gene function in mammalian cells. This approach enables researchers to identify gene function in a given biological context and will provide considerable novel insight. Here, we review RNAi HTS strategies and applications using case studies in cancer biology and virology.

Item Type: Publication - Article
Digital Object Identifier (DOI): 10.1007/s13238-014-0076-6
CEH Sections: CEH fellows
ISSN: 1674-800X
Additional Information. Not used in RCUK Gateway to Research.: Open Access paper - Official URL link provides full text
Additional Keywords: RNA interference (RNAi), short interfering RNA (siRNA), short hairpin RNA (shRNA), high-throughput screening, cancer, virology
NORA Subject Terms: Health
Medicine
Biology and Microbiology
Date made live: 12 Nov 2014 12:01 +0 (UTC)
URI: http://nora.nerc.ac.uk/id/eprint/508797

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