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Analyses on mutation patterns, detection of population bottlenecks, and suggestion of deleterious-compensatory evolution among members of the genus Potyvirus

Wang, H.; Huang, L. F.; Cooper, J. I.. 2006 Analyses on mutation patterns, detection of population bottlenecks, and suggestion of deleterious-compensatory evolution among members of the genus Potyvirus. Archives of Virology, 151. 1625-1633. 10.1007/s00705-006-0741-z

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Abstract/Summary

Viruses of the family Potyviridae exhibited a robust single-nucleotide polymorphism profile at the between-species level, conforming to the neutral theory rule. However, the ratios of nonsynonymous to synonymous mutations (Ka/Ks) were relatively greater between-species than within-species in viral cistrons examined from members of the genus Potyvirus, indicating a relaxation on constraint. Judged by the McDonald and Kreitman’s test, the fixation frequencies for nonsynonymous mutations across the genomes of closely related potyviruses were greater than expected, suggesting population bottlenecks at speciation. These mutation patterns are best explained by a deleterious-compensatory model.

Item Type: Publication - Article
Digital Object Identifier (DOI): 10.1007/s00705-006-0741-z
Programmes: CEH Programmes pre-2009 publications > Biodiversity
CEH Sections: _ Pathogen Population Ecology
ISSN: 0304-8608
Additional Information. Not used in RCUK Gateway to Research.: The original publication is available at www.springerlink.com
NORA Subject Terms: Biology and Microbiology
Date made live: 21 Jun 2007 12:49
URI: http://nora.nerc.ac.uk/id/eprint/507

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