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Exposed and concealed antigens as vaccine targets for controlling ticks and tick-borne diseases

Nuttall, P. A.; Trimnell, A. R.; Kazimirova, M.; Labuda, M.. 2006 Exposed and concealed antigens as vaccine targets for controlling ticks and tick-borne diseases. Parasite Immunology, 28 (4). 155-163. 10.1111/j.1365-3024.2006.00806.x

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Abstract/Summary

Tick vaccines derived from Bm86, a midgut membrane-bound protein of the cattle tick, Boophilus microplus, are currently the only commercially available ectoparasite vaccines. Despite its introduction to the market in 1994, and the recognized need for alternatives to chemical pesticides, progress in developing effective antitick vaccines (and ectoparasite vaccines in general) is slow. The primary rate-limiting step is the identification of suitable antigenic targets for vaccine development. Two sources of candidate vaccine antigens have been identified: 'exposed' antigens that are secreted in tick saliva during attachment and feeding on a host and 'concealed' antigens that are normally hidden from the host. Recently, a third group of antigens has been distinguished that combines the properties of both exposed and concealed antigens. This latter group offers the prospect of a broad-spectrum vaccine effective against both adults and immature stages of a wide variety of tick species. It also shows transmission-blocking and protective activity against a tick-borne pathogen. With the proliferation of molecular techniques and their application to vaccine development, there are high hopes for new and effective antitick vaccines that also control tick-borne diseases

Item Type: Publication - Article
Digital Object Identifier (DOI): 10.1111/j.1365-3024.2006.00806.x
Programmes: CEH Programmes pre-2009 publications > Biodiversity
CEH Sections: _ Molecular Virology & Parasitology
ISSN: 0141-9838
Format Availability: Electronic, Print
Additional Keywords: concealed antigens, dual acting tick vaccine, exposed antigens, tick vaccines
NORA Subject Terms: Biology and Microbiology
Date made live: 03 Jul 2007 11:30
URI: http://nora.nerc.ac.uk/id/eprint/424

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