Detection of seroconversion to West Nile virus, Usutu virus and Sindbis virus in UK sentinel chickens

Buckley, Alan; Dawson, Alistair; Gould, Ernest A.. 2006 Detection of seroconversion to West Nile virus, Usutu virus and Sindbis virus in UK sentinel chickens. Virology Journal, 3. 71. 10.1186/1743-422X-3-71

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Abstract/Summary

We previously reported evidence of West Nile virus (WNV) circulation in UK birds, probably introduced by migratory birds from overseas. We now demonstrate WNV-specific seroconversion in sentinel chickens raised on an English farm. Maternal neutralizing antibodies to WNV in hatchlings declined within three weeks. During the following months, healthy chickens developed WNV neutralizing antibodies that were confirmed by immunoblotting and indirect immunofluorescence tests using WNV antigens. The proportion of seropositive chickens was higher for WNV than for Usutu virus or Sindbis virus. Attempts to isolate infectious virus or to detect viral RNA in the sera, failed.

Item Type:	Article
Identification Number/DOI:	10.1186/1743-422X-3-71
Programmes:	CEH Programmes pre-2009 publications > Biodiversity
CEH Sections:	_ Ecological Risk _ Molecular Virology & Parasitology
NORA Subject Terms:	Biology and Microbiology
Date made live:	25 Apr 2008 08:45
URI:	http://nora.nerc.ac.uk/id/eprint/2273

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