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The M5nr: a novel non-redundant database containing protein sequences and annotations from multiple sources and associated tools

Wilke, Andreas; Harrison, Travis; Wilkening, Jared; Field, Dawn; Glass, Elizabeth M.; Kyrpides, Nikos; Mavrommatis, Konstantinos; Meyer, Folker. 2012 The M5nr: a novel non-redundant database containing protein sequences and annotations from multiple sources and associated tools. BMC Bioinformatics, 13 (1). 141. 10.1186/1471-2105-13-141

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Abstract/Summary

Background Computing of sequence similarity results is becoming a limiting factor in metagenome analysis. Sequence similarity search results encoded in an open, exchangeable format have the potential to limit the needs for computational reanalysis of these data sets. A prerequisite for sharing of similarity results is a common reference. Description We introduce a mechanism for automatically maintaining a comprehensive, non-redundant protein database and for creating a quarterly release of this resource. In addition, we present tools for translating similarity searches into many annotation namespaces, e.g. KEGG or NCBI's GenBank. Conclusions The data and tools we present allow the creation of multiple result sets using a single computation, permitting computational results to be shared between groups for large sequence data sets.

Item Type: Publication - Article
Digital Object Identifier (DOI): 10.1186/1471-2105-13-141
Programmes: CEH Topics & Objectives 2009 - 2012 > Biodiversity
Groups/Sections (CEH only): Hails
ISSN: 1471-2105
Additional Information. Not used in RCUK Gateway to Research.: This is an open access article. To access full text, click on the Official URL link
NORA Subject Terms: Biology and Microbiology
Data and Information
Date made live: 21 Jan 2013 13:59 +0 (UTC)
URI: http://nora.nerc.ac.uk/id/eprint/21175

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