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Tick cell lines: tools for tick and tick-borne disease research

Bell-Sakyi, Lesley; Zweygarth, Erich; Blouin, Edmour F.; Gould, Ernest A.; Jongejan, Frans. 2007 Tick cell lines: tools for tick and tick-borne disease research. Trends in Parasitology, 23 (9). 450-457. 10.1016/j.pt.2007.07.009

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Abstract/Summary

Over 40 cell lines are currently available from 13 ixodid and one argasid tick species. The successful isolation and propagation of several economically important tick-borne pathogens in tick cell lines has created a useful model to study interactions between tick cells and these viral and bacterial disease agents. Tick cell lines have already proved to be a useful tool in helping to define the complex nature of the host–vector–pathogen relationship. With the availability of genomics tools, tick cell lines will become increasingly important as a complement to tick and tick-borne disease research in vivo once genetic transformation and gene silencing using RNA interference become routine.

Item Type: Publication - Article
Digital Object Identifier (DOI): 10.1016/j.pt.2007.07.009
Programmes: CEH Programmes pre-2009 publications > Biodiversity
CEH Sections: Hails
CEH fellows
ISSN: 1471-4922
NORA Subject Terms: Biology and Microbiology
Medicine
Date made live: 15 Jan 2008 16:41
URI: http://nora.nerc.ac.uk/id/eprint/2103

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