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Molecular evolution of the insect-specific flaviviruses

Cook, Shelley; Moureau, Gregory; Kitchen, Andrew; Gould, Ernest A.; de Lamballerie, Xavier; Holmes, Edward C.; Harbach, Ralph E.. 2012 Molecular evolution of the insect-specific flaviviruses. Journal of General Virology, 93 (2). 223-234. 10.1099/vir.0.036525-0

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Abstract/Summary

There has been an explosion in the discovery of ‘insect-specific’ flaviviruses and/or their related sequences in natural mosquito populations. Herein we review all ‘insect-specific’ flavivirus sequences currently available and conduct phylogenetic analyses of both the ‘insect-specific’ flaviviruses and available sequences of the entire genus Flavivirus. We show that there is no statistical support for virus–mosquito co-divergence, suggesting that the ‘insect-specific’ flaviviruses may have undergone multiple introductions with frequent host switching. We discuss potential implications for the evolution of vectoring within the family Flaviviridae. We also provide preliminary evidence for potential recombination events in the history of cell fusing agent virus. Finally, we consider priorities and guidelines for future research on ‘insect-specific’ flaviviruses, including the vast potential that exists for the study of biodiversity within a range of potential hosts and vectors, and its effect on the emergence and maintenance of the flaviviruses.

Item Type: Publication - Article
Digital Object Identifier (DOI): 10.1099/vir.0.036525-0
Programmes: CEH Topics & Objectives 2009 - 2012 > Biodiversity
CEH Sections: CEH fellows
ISSN: 0022-1317
Additional Information. Not used in RCUK Gateway to Research.: This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited
NORA Subject Terms: Biology and Microbiology
Date made live: 17 Jan 2013 15:46 +0 (UTC)
URI: http://nora.nerc.ac.uk/id/eprint/20960

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