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Arthropod-derived protein EV131 inhibits histamine action and allergic asthma

Weston-Davies, Wynne; Coullin, Isabelle; Schnyder, Silvia; Schnyder, Bruno; Moser, Rene; Lissina, Olga; Paesen, Guido C.; Nuttall, Patricia; Ryffel, Bernhard. 2005 Arthropod-derived protein EV131 inhibits histamine action and allergic asthma. Annals of the New York Academy of Sciences, 1056. 189-196. 10.1196/annals.1352.009

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Abstract/Summary

Histamine is an important mediator of allergic responses. Arthropods express several biologically active proteins in their saliva, which may allow a prolonged blood meal on the host. Proteins identified and expressed include histamine, serotonin, tryptase, and complement binding proteins. We review here data that scavenging of endogenous histamine by the histamine-binding protein EV131 has a profound inhibitory effect on allergic asthma. Aerosol administration of EV131 prevented airway hyperreactivity and abrogated peribronchial inflammation, eosinophil recruitment, mucus hypersecretion, and IL-4 and IL-5 secretion. Saturation with histamine abrogated the inhibitory effect of EV131 on bronchial hyperreactivity. The data suggest that histamine plays a role in allergies and that scavenging of histamine by EV131 may represent a novel therapeutic strategy in the treatment of allergic diseases.

Item Type: Publication - Article
Digital Object Identifier (DOI): 10.1196/annals.1352.009
Programmes: CEH Programmes pre-2009 publications > Biodiversity
CEH Sections: Directors, SPCs
ISSN: 1749-6632
Additional Keywords: endotoxin, adult respiratory distress syndrome, histamine scavenging, mice
NORA Subject Terms: Biology and Microbiology
Related URLs:
Date made live: 11 Dec 2012 15:21 +0 (UTC)
URI: http://nora.nerc.ac.uk/id/eprint/20013

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