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A cross-reactive tick cement antigen is a candidate broad-spectrum tick vaccine

Trimnell, Adama R.; Davies, Gillian M.; Lissina, Olga; Hails, Rosie S.; Nuttall, Patricia A. . 2005 A cross-reactive tick cement antigen is a candidate broad-spectrum tick vaccine. Vaccine, 23 (34). 4329-4341. 10.1016/j.vaccine.2005.03.041

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Abstract/Summary

Truncated constructs of 64P (64TRPs), a secreted cement protein from salivary glands of the tick Rhipicephalus appendiculatus, provided cross-protection against Rhipicephalus sanguineus and Ixodes ricinus, apparently by targeting antigens in the midgut and salivary glands of adults and nymphs, causing mortality. Tick feeding on 64TRP-immunised animals stimulated local inflammatory immune responses (involving basophils, eosinophils, lymphocytes, mast cells, macrophages and dendritic-like cells) that boosted the immune status of vaccinated animals. The vaccine trial results, and antigenic cross-reactivity of 64TRPs with R. sanguineus, I. ricinus, Amblyomma variegatum and Boophilus microplus, indicate the potential of 64TRPs as a broad-spectrum anti-tick vaccine.

Item Type: Publication - Article
Digital Object Identifier (DOI): 10.1016/j.vaccine.2005.03.041
Programmes: CEH Programmes pre-2009 publications > Biodiversity
CEH Sections: Directors, SPCs
_ Pathogen Population Ecology
ISSN: 0264-410X
Additional Keywords: tick vaccine, tick cement, Rhipicephalus appendiculatus, Rhipicephalus sanguineus, Ixodes ricinus, Boophilus microplus; Amblyomma variegatum
NORA Subject Terms: Biology and Microbiology
Date made live: 11 Dec 2012 15:31 +0 (UTC)
URI: http://nora.nerc.ac.uk/id/eprint/20012

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