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Arthropod-derived histamine-binding protein prevents murine allergic asthma

Couillin, Isabelle; Maillet, Isabelle; Vargaftig, B.Boris; Jacobs, Muazzam; Paesen, Guido C.; Nuttall, Patricia A.; Lefort, Jean; Moser, Rene; Weston-Davies, Wynne; Ryffel, Bernhard. 2004 Arthropod-derived histamine-binding protein prevents murine allergic asthma. The Journal of Immunology, 173 (5). 3281-3286.

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Abstract/Summary

Because histamine receptor type I blockade attenuates allergic asthma, we asked whether complete neutralization of histamine by an arthropod-derived, high affinity histamine-binding protein (EV131) would prevent allergic asthma. Intranasal administration of EV131 given before Ag challenge in immunized mice prevented airway hyperreactivity by 70%, and abrogated peribronchial inflammation, pulmonary eosinophilia, mucus hypersecretion, and IL-4 and IL-5 secretion. Saturation with histamine abrogated the inhibitory effect of EV131 on bronchial hyperreactivity. The inhibitory effect of EV131 on bronchial hyperreactivity was comparable to that of glucocorticosteroids. These results demonstrate that histamine is a critical mediator of allergic asthma. Therefore, complete neutralization of histamine, rather than specific histamine receptor blockade, may have a profound effect on allergic asthma.

Item Type: Publication - Article
Programmes: CEH Programmes pre-2009 publications > Biodiversity
CEH Sections: Directors, SPCs
_ Molecular Virology & Parasitology
ISSN: 0022-1767
NORA Subject Terms: Biology and Microbiology
Date made live: 12 Dec 2012 11:24 +0 (UTC)
URI: http://nora.nerc.ac.uk/id/eprint/20007

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