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Modelling in molecular biology: describing transcription regulatory networks at different scales

Schlitt, Thomas; Brazma, Alvis. 2006 Modelling in molecular biology: describing transcription regulatory networks at different scales. Philosophical Transactions of the Royal Society (B), 361 (1467). 483-494. 10.1098/rstb.2005.1806

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Abstract/Summary

Approaches to describe gene regulation networks can be categorized by increasing detail, as network parts lists, network topology models, network control logic models or dynamic models. We discuss the current state of the art for each of these approaches. We study the relationship between different topology models, and give examples how they can be used to infer functional annotations for genes of unknown function. We introduce a new simple way of describing dynamic models called finite state linear model (FSLM). We discuss the gap between the parts list and topology models on one hand, and network logic and dynamic models, on the other hand. The first two classes of models have reached a genome-wide scale, while for the other model classes high-throughput technologies are yet to make a major impact.

Item Type: Publication - Article
Digital Object Identifier (DOI): 10.1098/rstb.2005.1806
Programmes: BAS Programmes > Global Science in the Antarctic Context (2005-2009) > Biodiversity, Functions, Limits and Adaptation from Molecules to Ecosystems
ISSN: 0962-8436
Format Availability: Electronic, Print
Additional Information. Not used in RCUK Gateway to Research.: Full text not available from this repository
Additional Keywords: Molecular biology
NORA Subject Terms: Biology and Microbiology
Date made live: 31 Jul 2007 12:53
URI: http://nora.nerc.ac.uk/id/eprint/117

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