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Elimination kinetic model for organic chemicals in earthworms

Dimitrova, N.; Dimitrov, S.; Georgieva, D.; Van Gestel, C.A.M.; Hankard, P.; Spurgeon, D.; Li, H.; Mekenyan, O.. 2010 Elimination kinetic model for organic chemicals in earthworms. Science of the Total Environment, 408. 3787-3793. 10.1016/j.scitotenv.2010.01.064

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Abstract/Summary

Mechanistic understanding of bioaccumulation in different organisms and environments should take into account the influence of organism and chemical depending factors on the uptake and elimination kinetics of chemicals. Lipophilicity, metabolism, sorption (bioavailability) and biodegradation of chemicals are among the important factors that may significantly affect the bioaccumulation process in soil organisms. This study attempts to model elimination kinetics of organic chemicals in earthworms by accounting for the effects of both chemical and biological properties, including metabolism. The modeling approach that has been developed is based on the concept for simulating metabolism used in the BCF base-line model developed for predicting bioaccumulation in fish. Metabolism was explicitly accounted for by making use of the TIMES engine for simulation of metabolism and a set of principal transformations. Kinetic characteristics of transformations were estimated on the basis of observed kinetics data for the elimination of organic chemicals from earthworms

Item Type: Publication - Article
Digital Object Identifier (DOI): 10.1016/j.scitotenv.2010.01.064
Programmes: CEH Topics & Objectives 2009 onwards > Biogeochemistry > BGC Topic 1 - Monitoring and Interpretation of Biogeochemical and Climate Changes
CEH Sections: Shore
Hails
ISSN: 0048-9697
Additional Keywords: QSAR, elimination, PAHs; earthworms
NORA Subject Terms: Biology and Microbiology
Ecology and Environment
Date made live: 28 Sep 2010 11:03
URI: http://nora.nerc.ac.uk/id/eprint/11014

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